IDENTIFYING MODIFIABLE ASPECTS OF GENE-BY-ENVIRONMENT INTERPLAY IN LATER-LIFE COGNITIVE DECLINE

 

OUR RESEARCH IN THE NEWS

Kevin Thom's research discussed in The Washington Post here

PAPERS PUBLISHED

  1. Faul, J.D., Ware, E.B., Kabeto, M.U., Langa, K.M. (2021), The effect of childhood socioeconomic position and social mobility on cognitive function and change among older adults: A comparison between the United States and England. (Journal of Gerontology – B). Forthcoming
  2. Marees, A.T., Smit, D.J.A., Abdellaoui, A., Nivard, M.G., van den Brink, W., Denys, D., Galama, T.J., Verweij, K.J.H., Derks, E.M. (2021), Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits, Nature Human Behavior, pp.1-9.
  3. Fonseca, R., Michaud, P., Galama, T.J. and Kapteyn, A. (2021). Accounting for the Rise of Health Spending and Longevity. Journal of the European Economic Association,19(1), pp.536-579.
  4. Barth, D., Papageorge, N. and Thom, K. (2020), Genetic Endowments and Wealth Inequality, Journal of Political Economy. doi: 10.1086/705415
  5. Papageorge, N. and Thom, K. (2019), Genes, Education, and Labor Market Outcomes: Evidence from the Health and Retirement Study, Journal of the European Economic Association. 
  6. Lourida, I., Hannon, E., Littlejohns, T.J., Langa, K.M., Hyppönen, E., Kuźma, E., and Llewellyn, D.J. (2019), Association of Lifestyle and Genetic Risk With Incidence of Dementia, Journal of the American Medical Association (JAMA), 322(5):430-437. doi:10.1001/jama.2019.9879
  7. Taylor, J.Y., Ware, E.B., Wright, M.L., Smith, J.A., Kardia, S.L.R. (2019), Using Genetic Burden Scores for Gene-by-Methylation Interaction Analysis on Metabolic Syndrome in African Americans. Biological Research for Nursing, 21(3): 279-285. doi: 10.1177/1099800419828486. Epub 2019 Feb 19. PubMed PMID: 30781968. ​
  8. Schmitz, L.L., Gard, A.M., Ware, E.B. (2019), Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques. American Journal of Medical Genetics, part B, Neuropsychiatric Genetics. doi: 10.1002/ajmg.b.32748. [Epub ahead of print] PubMed PMID: 31219244; NIHMSID:NIHMS1042483.  
  9. Barcellos, S.H., Carvalho, S., Turley, P. (2018), Education can Reduce Health Differences Related to Genetic Risk of Obesity, Proceedings of the National Academy of Sciences (PNAS) of the United States  
  10. Smith, J.A., Kho, M., Zhao, W., Yu, M., Mitchell, C., Faul, J.D. (2018), Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population. Social science & medicine (1982). 2018 November 10. PubMed PMID: 30449520; PubMed Central PMCID: PMC6510651; DOI: 10.1016/j.socscimed.2018.11.019.​
  11. Galama, T.J., Lleras-Muney, A. and Van Kippersluis, H. (2018), The Effect of Education on Health and Mortality: A Review of Experimental and Quasi-Experimental Evidence. Oxford Research Encyclopedia of Economics and Finance. Link to working paper. doi:10.1093/acrefore/9780190625979.013.7
  12. Galama, T.J. and van Kippersluis H.  (2018). A Theory of Socioeconomic Disparities in Health Over the Life Cycle. Economic Journal; Link to working paper.
  13. Kuźma, E., Hannon, E., Zhou, A., Lourida, I., Bethel, A., Levine, D.A., Lunnon, K., Thompson-Coon, J., Hyppönen, E., and Llewellyn, D.(2018), Which risk factors causally influence dementia? A systematic review of Mendelian randomization studies, Journal of Alzheimer’s Disease, 64, pp. 181–193
  14. Kuźma, E., Lourida, A., Moore, S.F., Levine, D.A., Obioha C. Ukoumunne, O.C., Llewellyn, D.J. (2018). Stroke and dementia risk: A systematic review and meta-analysis. Alzheimers & Dementia, 1-11

WORKING PAPERS / PAPERS SUBMITTED

  1. Van Kippersluis, H., Biroli, P., Galama, T.J., Von Hinke, S., Meddens, F.W., Muslimova, D., Pereira, R., and Rietveld, C.A. (2021), Stop Meta-Analyzing, Start Instrumenting: Maximizing the Predictive Power of Polygenic Scores. Link to working paper (doi: https://doi.org/10.1101/2021.04.09.439157)
  2. Barcellos, S., Carvalho, L. and Turley, P. (2020). Is Education the Great Equalizer? Link to working paper.
  3. Bakulski, K.M., Vadari, H.S., Faul, J.D., Heeringa, S.G., Kardia, S.L.R., Langa, K.M., Smith, J.A., Manly, J.J., Mitchell, C.M., Benke, K.S., Ware, E.B. (2020). A non-APOE polygenic score for Alzheimer's disease and APOE-ε4 have independent associations with dementia in the Health and Retirement Study (medRxiv). 2020.02.10.20021667; doi: https://doi.org/10.1101/2020.02.10.20021667 (R&R Neurology). Link to working paper. 
  4. Fu, M., Ware, E.B., Faul, J.D., Bakulski, K.M. (2020), Mendelian randomization of smoking behavior on cognitive status among older Americans. (medRxiv) 2019.12.11.19014522; doi: https://doi.org/10.1101/2019.12.11.19014522. Link to working paper.
  5. Ware, E.B., Faul, J.D., Mitchell, C.M., and Bakulski, K.M. (2019), Considering the APOE locus in polygenic scores for Alzheimer's disease, MedRXiv. Link to working paper. (R&R BMC Genomic Medicine)
  6. Barcellos, S., Carvalho, L. and Turley, P. (2019). Distributional Effects of Education on Health (May 2019). NBER Working Paper No. w25898.
  7. Bierut, L., Biroli, P., Galama, T.J., and Thom, K. (2018). Childhood socioeconomic status moderates genetic predisposition for peak smoking. Link to working paper.
  8. Ware, E.B., Schmitz, L.L., Faul, J.D., Gard, A., Mitchell, C., Smith, J.A., Zhao, W., Weir, D., Kardia, S.L.R. (2019), Heterogeneity in polygenic scores for common human traits. In review.
  9. Bakulski, K.M., Petrowicz, B., Vadari, H., Faul, J.D., Manly, J., Kardia, S.K., Heeringa, S., Ware, E.B. (2019), Early life exposures and risk for dementia in the Health and Retirement Study. In preparation​
  10. Faul, J.D., Benke, K., Bakulski, K.M., Ware, E.B. (2019), Within and Trans-Racial PGS and Gene-Region Associations. In preparation.
  11. Brandt, D., Bakulski, K.M., Faul, J.D., Vadari, H.S., Ware, E.B. (2019) Occupational mental and physical work demands associated with cognitive status in older Americans. In preparation.
  12. Marshall III, W., Ware, E.B., Faul, J.D., Vadari, H.S., Bakulski, K.M. (2019), Family history of Alzheimer’s Disease and cumulative genetic risk in older Americans. In preparation.
  13. Faul, J.D., Ware, E.B., Kabeto, M.U., Langa, K.M., Llewellyn, D.J., Galama, T. Lifestyle and Genetic Risk: Revisiting the Association with Incident Dementia. In preparation.