IDENTIFYING MODIFIABLE ASPECTS OF GENE-BY-ENVIRONMENT INTERPLAY IN LATER-LIFE COGNITIVE DECLINE

 

 

OUR RESEARCH IN THE NEWS

Kevin Thom's research discussed in The Washington Post here

PAPERS PUBLISHED

  1. Okbay et al. (2022), Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals, Nature Genetics. 54:437-449 (2022)
  2. Dias-Pereira, R., Biroli, P., Galama, T.J., von Hinke, S., van Kippersluis, H., Rietveld, C.A., and Thom, K. (2022), Gene-by-Environment Interplay in the Social Sciences. Oxford Research Encyclopedia of Economics and Finance. Working Paper.
  3. Barcellos, S., Carvalho, L. and Turley, P. (2021). Distributional Effects of Education on Health (2021), Forthcoming at the Journal of Human Resources. NBER Working Paper No. w25898.
  4. Faul, J.D., Ware, E.B., Kabeto, M.U., Langa, K.M. (2021), The effect of childhood socioeconomic position and social mobility on cognitive function and change among older adults: A comparison between the United States and England, Journal of Gerontology, Series B, 76, pS51-S63.
  5. Marees, A.T., Smit, D.J.A., Abdellaoui, A., Nivard, M.G., van den Brink, W., Denys, D., Galama, T.J., Verweij, K.J.H., Derks, E.M. (2021), Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits, Nature Human Behavior, pp.1-9.
  6. Fonseca, R., Michaud, P., Galama, T.J. and Kapteyn, A. (2021). Accounting for the Rise of Health Spending and Longevity. Journal of the European Economic Association,19(1), pp.536-579.
  7. Faul, J.D., Ware, E.B., Kabeto, M.U., Langa, K.M., Llewellyn, D.J., Galama, T. (2020), Lifestyle and Genetic Risk: Revisiting the Association with Incident Dementia. Alzheimer's & Dementia, 2020 16:e044220.
  8. Barth, D., Papageorge, N. and Thom, K. (2020), Genetic Endowments and Wealth Inequality, Journal of Political Economy. doi: 10.1086/705415
  9. Papageorge, N. and Thom, K. (2019), Genes, Education, and Labor Market Outcomes: Evidence from the Health and Retirement Study, Journal of the European Economic Association. 
  10. Lourida, I., Hannon, E., Littlejohns, T.J., Langa, K.M., Hyppönen, E., Kuźma, E., and Llewellyn, D.J. (2019), Association of Lifestyle and Genetic Risk With Incidence of Dementia, Journal of the American Medical Association (JAMA), 322(5):430-437. doi:10.1001/jama.2019.9879
  11. Taylor, J.Y., Ware, E.B., Wright, M.L., Smith, J.A., Kardia, S.L.R. (2019), Using Genetic Burden Scores for Gene-by-Methylation Interaction Analysis on Metabolic Syndrome in African Americans. Biological Research for Nursing, 21(3): 279-285. doi: 10.1177/1099800419828486. Epub 2019 Feb 19. PubMed PMID: 30781968. ​
  12. Schmitz, L.L., Gard, A.M., Ware, E.B. (2019), Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques. American Journal of Medical Genetics, part B, Neuropsychiatric Genetics. doi: 10.1002/ajmg.b.32748. [Epub ahead of print] PubMed PMID: 31219244; NIHMSID:NIHMS1042483.  
  13. Barcellos, S.H., Carvalho, S., Turley, P. (2018), Education can Reduce Health Differences Related to Genetic Risk of Obesity, Proceedings of the National Academy of Sciences (PNAS) of the United States  
  14. Smith, J.A., Kho, M., Zhao, W., Yu, M., Mitchell, C., Faul, J.D. (2018), Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population. Social science & medicine (1982). 2018 November 10. PubMed PMID: 30449520; PubMed Central PMCID: PMC6510651; DOI: 10.1016/j.socscimed.2018.11.019.​
  15. Galama, T.J., Lleras-Muney, A. and Van Kippersluis, H. (2018), The Effect of Education on Health and Mortality: A Review of Experimental and Quasi-Experimental Evidence. Oxford Research Encyclopedia of Economics and Finance. Link to working paper. doi:10.1093/acrefore/9780190625979.013.7
  16. Galama, T.J. and van Kippersluis H.  (2018). A Theory of Socioeconomic Disparities in Health Over the Life Cycle. Economic Journal; Link to working paper.
  17. Kuźma, E., Hannon, E., Zhou, A., Lourida, I., Bethel, A., Levine, D.A., Lunnon, K., Thompson-Coon, J., Hyppönen, E., and Llewellyn, D.(2018), Which risk factors causally influence dementia? A systematic review of Mendelian randomization studies, Journal of Alzheimer’s Disease, 64, pp. 181–193
  18. Kuźma, E., Lourida, A., Moore, S.F., Levine, D.A., Obioha C. Ukoumunne, O.C., Llewellyn, D.J. (2018). Stroke and dementia risk: A systematic review and meta-analysis. Alzheimers & Dementia, 1-11

WORKING PAPERS / PAPERS SUBMITTED

  1. Galama, T.J. and van Kippersluis, H. (2022), Human-Capital Formation: The Importance of Endogenous Longevity. Human Capital and Economic Opportunity Global Working Group, Working Paper 2022-009 
  2. Van Alten, S., Domingue, B.W., Galama, T.J. and Marees, A.T. (2022), Reweighting the UK Biobank to reflect its underlying sampling population substantially reduces pervasive selection bias due to volunteering. Working Paper.
  3. Van Alten, S., Domingue, B.W., Galama, T.J., Marees, A.T. and Faul, J. (2022), The effects of demographic-based selection bias on GWAS results in the UK Biobank. 
  4. Carvalho, L. (2022), Genetics, Economic Choices, and Income. In preparation.
  5. Van Alten, S. and Galama, T. (2021), Genetic and environmental determinants of socioeconomic status: evidence from within-family models in the Dutch Lifelines cohort. In preparation.
  6. Aranda, R., Galama, T., and Thom, K. (2022), The Long-Run Health Consequences of Title IX. In preparation
  7. Galama, T., Munteanu, A and Thom, K. (2022), Intergenerational Consequences of Compulsory Schooling. In preparation.
  8. Van Kippersluis, H., Biroli, P.. Galama, T.J., Muslimova, D., Meddens, F., von Hinke, S., Pereira, R., Rietveld, N., Using Obviously-Related Instrumental Variables to Increase the Predictive Power of Polygenic Scores, R&R at Nature Communications. Link to working paper
  9. Bakulski, K.M., Vadari, H.S., Faul, J.D., Heeringa, S.G., Kardia, S.L.R., Langa, K.M., Smith, J.A., Manly, J.J., Mitchell, C.M., Benke, K.S., Ware, E.B. (2020). A non-APOE polygenic score for Alzheimer's disease and APOE-ε4 have independent associations with dementia in the Health and Retirement Study (medRxiv). 2020.02.10.20021667; doi: https://doi.org/10.1101/2020.02.10.20021667 (R&R Neurology). Link to working paper. 
  10. Barcellos, S., Carvalho, L. and Turley, P. (2021). The Effect of Education on the Relationship between Genetics, Early-Life Disadvantages, and Later-Life SES (under revision at the Journal of Political Economy). NBER Working Paper No. w28750
  11. Fu, M., Ware, E.B., Faul, J.D., Bakulski, K.M. (2020), Mendelian randomization of smoking behavior on cognitive status among older Americans. (medRxiv) 2019.12.11.19014522; doi: https://doi.org/10.1101/2019.12.11.19014522. Link to working paper.
  12. Ware, E.B., Faul, J.D., Mitchell, C.M., and Bakulski, K.M. (2019), Considering the APOE locus in polygenic scores for Alzheimer's disease, MedRXiv. Link to working paper. (R&R BMC Genomic Medicine)
  13. Bierut, L., Biroli, P., Galama, T.J., and Thom, K. (2018). Childhood socioeconomic status moderates genetic predisposition for peak smoking. Link to working paper.
  14. Ware, E.B., Schmitz, L.L., Faul, J.D., Gard, A., Mitchell, C., Smith, J.A., Zhao, W., Weir, D., Kardia, S.L.R. (2019), Heterogeneity in polygenic scores for common human traits. In review.
  15. Barth, D., Papageorge, N.W., and Thom, K. (2021), Genetic endowments, income dynamics, and wealth accumulation over the lifecycle. In preparation. 
  16. Jeong, Y., Papageorge, N.W., Skira, M.M. and Thom, K. (2021), Genetic endowments, Alzheimer's disease, and economic outcomes. In preparation.
  17. Van Alten, S., Galama, T.J. and Thom, K. (2021), The distributional consequences of region-specific exposure to Chinese import competition: evidence from a shift-share analysis (1990-2010). In preparation.
  18. Warly Solsberg, C., van Alten, S., Geier, E.G., Bonham, L., Derks, E.M., Sirota, M., Galama, T.J., Yokoyama, J.S., Marees, A.T. (2021), Conducting a genome wide association study: a roadmap and tutorial. In preparation.
  19. Angrisani, Faul, J., Galama, T. and Kabeto, M. (2021), Money Management Problems as a Precursor of Cognitive Impairment and Dementia. In preparation
  20. Biroli, P., Galama, T.J., Marees, A., et al. (2021), Sources of Inequality at Birth:  the Interplay Between Genes and Parental Socioeconomic Status. In preparation
  21. Biroli, P., Galama, T.J., von Hinke, S., van Kippersluis, H., Rietveld, C.A., and Thom, K. (2021), The Economics and Econometrics of Gene-Environment Interplay. Working Paper.
  22. Bakulski, K.M., Petrowicz, B., Vadari, H., Faul, J.D., Manly, J., Kardia, S.K., Heeringa, S., Ware, E.B. (2019), Early life exposures and risk for dementia in the Health and Retirement Study. In preparation​
  23. Faul, J.D., Benke, K., Bakulski, K.M., Ware, E.B. (2019), Within and Trans-Racial PGS and Gene-Region Associations. In preparation.
  24. Brandt, D., Bakulski, K.M., Faul, J.D., Vadari, H.S., Ware, E.B. (2019) Occupational mental and physical work demands associated with cognitive status in older Americans. In preparation.
  25. Marshall III, W., Ware, E.B., Faul, J.D., Vadari, H.S., Bakulski, K.M. (2019), Family history of Alzheimer’s Disease and cumulative genetic risk in older Americans. In preparation.