IDENTIFYING MODIFIABLE ASPECTS OF GENE-BY-ENVIRONMENT INTERPLAY IN LATER-LIFE COGNITIVE DECLINE

 

 

OUR RESEARCH IN THE NEWS

Kevin Thom's research discussed in The Washington Post here

PAPERS PUBLISHED

  1. Barcellos, S., Carvalho, L. and Turley, P. (2021). Distributional Effects of Education on Health (2021), Forthcoming at the Journal of Human Resources. NBER Working Paper No. w25898.
  2. Faul, J.D., Ware, E.B., Kabeto, M.U., Langa, K.M. (2021), The effect of childhood socioeconomic position and social mobility on cognitive function and change among older adults: A comparison between the United States and England, Journal of Gerontology, Series B, 76, pS51-S63.
  3. Marees, A.T., Smit, D.J.A., Abdellaoui, A., Nivard, M.G., van den Brink, W., Denys, D., Galama, T.J., Verweij, K.J.H., Derks, E.M. (2021), Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits, Nature Human Behavior, pp.1-9.
  4. Fonseca, R., Michaud, P., Galama, T.J. and Kapteyn, A. (2021). Accounting for the Rise of Health Spending and Longevity. Journal of the European Economic Association,19(1), pp.536-579.
  5. Barth, D., Papageorge, N. and Thom, K. (2020), Genetic Endowments and Wealth Inequality, Journal of Political Economy. doi: 10.1086/705415
  6. Papageorge, N. and Thom, K. (2019), Genes, Education, and Labor Market Outcomes: Evidence from the Health and Retirement Study, Journal of the European Economic Association. 
  7. Lourida, I., Hannon, E., Littlejohns, T.J., Langa, K.M., Hyppönen, E., Kuźma, E., and Llewellyn, D.J. (2019), Association of Lifestyle and Genetic Risk With Incidence of Dementia, Journal of the American Medical Association (JAMA), 322(5):430-437. doi:10.1001/jama.2019.9879
  8. Taylor, J.Y., Ware, E.B., Wright, M.L., Smith, J.A., Kardia, S.L.R. (2019), Using Genetic Burden Scores for Gene-by-Methylation Interaction Analysis on Metabolic Syndrome in African Americans. Biological Research for Nursing, 21(3): 279-285. doi: 10.1177/1099800419828486. Epub 2019 Feb 19. PubMed PMID: 30781968. ​
  9. Schmitz, L.L., Gard, A.M., Ware, E.B. (2019), Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques. American Journal of Medical Genetics, part B, Neuropsychiatric Genetics. doi: 10.1002/ajmg.b.32748. [Epub ahead of print] PubMed PMID: 31219244; NIHMSID:NIHMS1042483.  
  10. Barcellos, S.H., Carvalho, S., Turley, P. (2018), Education can Reduce Health Differences Related to Genetic Risk of Obesity, Proceedings of the National Academy of Sciences (PNAS) of the United States  
  11. Smith, J.A., Kho, M., Zhao, W., Yu, M., Mitchell, C., Faul, J.D. (2018), Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population. Social science & medicine (1982). 2018 November 10. PubMed PMID: 30449520; PubMed Central PMCID: PMC6510651; DOI: 10.1016/j.socscimed.2018.11.019.​
  12. Galama, T.J., Lleras-Muney, A. and Van Kippersluis, H. (2018), The Effect of Education on Health and Mortality: A Review of Experimental and Quasi-Experimental Evidence. Oxford Research Encyclopedia of Economics and Finance. Link to working paper. doi:10.1093/acrefore/9780190625979.013.7
  13. Galama, T.J. and van Kippersluis H.  (2018). A Theory of Socioeconomic Disparities in Health Over the Life Cycle. Economic Journal; Link to working paper.
  14. Kuźma, E., Hannon, E., Zhou, A., Lourida, I., Bethel, A., Levine, D.A., Lunnon, K., Thompson-Coon, J., Hyppönen, E., and Llewellyn, D.(2018), Which risk factors causally influence dementia? A systematic review of Mendelian randomization studies, Journal of Alzheimer’s Disease, 64, pp. 181–193
  15. Kuźma, E., Lourida, A., Moore, S.F., Levine, D.A., Obioha C. Ukoumunne, O.C., Llewellyn, D.J. (2018). Stroke and dementia risk: A systematic review and meta-analysis. Alzheimers & Dementia, 1-11

WORKING PAPERS / PAPERS SUBMITTED

  1. Bakulski, K.M., Vadari, H.S., Faul, J.D., Heeringa, S.G., Kardia, S.L.R., Langa, K.M., Smith, J.A., Manly, J.J., Mitchell, C.M., Benke, K.S., Ware, E.B. (2020). A non-APOE polygenic score for Alzheimer's disease and APOE-ε4 have independent associations with dementia in the Health and Retirement Study (medRxiv). 2020.02.10.20021667; doi: https://doi.org/10.1101/2020.02.10.20021667 (R&R Neurology). Link to working paper. 
  2. Dias-Pereira, R., Biroli, P., Galama, T.J., von Hinke, S., van Kippersluis, H., Rietveld, C.A., and Thom, K. (2021), Gene-by-Environment Interplay. Forthcoming in Oxford Research Encyclopedia of Economics and Finance. 
  3. Barcellos, S., Carvalho, L. and Turley, P. (2021). The Effect of Education on the Relationship between Genetics, Early-Life Disadvantages, and Later-Life SES (under revision at the Journal of Political Economy). NBER Working Paper No. w28750
  4. Van Kippersluis, H., Biroli, P., Galama, T.J., Von Hinke, S., Meddens, F.W., Muslimova, D., Pereira, R., and Rietveld, C.A. (2021), Stop Meta-Analyzing, Start Instrumenting: Maximizing the Predictive Power of Polygenic Scores. Under review Nature Communications. Link to working paper (doi: https://doi.org/10.1101/2021.04.09.439157)
  5. Fu, M., Ware, E.B., Faul, J.D., Bakulski, K.M. (2020), Mendelian randomization of smoking behavior on cognitive status among older Americans. (medRxiv) 2019.12.11.19014522; doi: https://doi.org/10.1101/2019.12.11.19014522. Link to working paper.
  6. Ware, E.B., Faul, J.D., Mitchell, C.M., and Bakulski, K.M. (2019), Considering the APOE locus in polygenic scores for Alzheimer's disease, MedRXiv. Link to working paper. (R&R BMC Genomic Medicine)
  7. Bierut, L., Biroli, P., Galama, T.J., and Thom, K. (2018). Childhood socioeconomic status moderates genetic predisposition for peak smoking. Link to working paper.
  8. Ware, E.B., Schmitz, L.L., Faul, J.D., Gard, A., Mitchell, C., Smith, J.A., Zhao, W., Weir, D., Kardia, S.L.R. (2019), Heterogeneity in polygenic scores for common human traits. In review.
  9. Barth, D., Papageorge, N.W., and Thom, K. (2021), Genetic endowments, income dynamics, and wealth accumulation over the lifecycle. In preparation. 
  10. Jeong, Y., Papageorge, N.W., Skira, M.M. and Thom, K. (2021), Genetic endowments, Alzheimer's disease, and economic outcomes. In preparation.
  11. Van Alten, S., Galama, T.J. and Thom, K. (2021), The distributional consequences of region-specific exposure to Chinese import competition: evidence from a shift-share analysis (1990-2010). In preparation.
  12. Warly Solsberg, C., van Alten, S., Geier, E.G., Bonham, L., Derks, E.M., Sirota, M., Galama, T.J., Yokoyama, J.S., Marees, A.T. (2021), Conducting a genome wide association study: a roadmap and tutorial. In preparation.
  13. Faul, J.D., Ware, E.B., Kabeto, M.U., Langa, K.M., Llewellyn, D.J., Galama, T. (2021), Lifestyle and Genetic Risk: Revisiting the Association with Incident Dementia. In preparation.
  14. Angrisani, Faul, J., Galama, T. and Kabeto, M. (2021), Money Management Problems as a Precursor of Cognitive Impairment and Dementia. In preparation
  15. Biroli, P., Galama, T.J., Marees, A., et al. (2021), Sources of Inequality at Birth:  the Interplay Between Genes and Parental Socioeconomic Status. In preparation
  16. Biroli, P., Galama, T.J., von Hinke, S., van Kippersluis, H., Rietveld, C.A., and Thom, K. (2021), The Economics and Econometrics of Gene-Environment Interplay. In preparation.
  17. Van Alten, S., Domingue, B.W., Galama, T.J. and Marees, A.T. (2021), The effects of demographic-based selection bias on GWAS results in the UK Biobank. In preparation.
  18. Bakulski, K.M., Petrowicz, B., Vadari, H., Faul, J.D., Manly, J., Kardia, S.K., Heeringa, S., Ware, E.B. (2019), Early life exposures and risk for dementia in the Health and Retirement Study. In preparation​
  19. Faul, J.D., Benke, K., Bakulski, K.M., Ware, E.B. (2019), Within and Trans-Racial PGS and Gene-Region Associations. In preparation.
  20. Brandt, D., Bakulski, K.M., Faul, J.D., Vadari, H.S., Ware, E.B. (2019) Occupational mental and physical work demands associated with cognitive status in older Americans. In preparation.
  21. Marshall III, W., Ware, E.B., Faul, J.D., Vadari, H.S., Bakulski, K.M. (2019), Family history of Alzheimer’s Disease and cumulative genetic risk in older Americans. In preparation.