IDENTIFYING MODIFIABLE ASPECTS OF GENE-BY-ENVIRONMENT INTERPLAY IN LATER-LIFE COGNITIVE DECLINE

 

OUR RESEARCH IN THE NEWS

Kevin Thom's research discussed in The Washington Post here

PAPERS PUBLISHED

  1. Lyall DM, Kormilitzin A, Lancaster C, Sousa J, Petermann-Rocha F, Buckley C, Harshfield EL, Iveson MH, Madan CR, McArdle R, Newby D, Orgeta V, Tang E, Tamburin S, Thakur LS, Lourida I; Deep Dementia Phenotyping (DEMON) Network; Llewellyn DJ, Ranson JM. Artificial intelligence for dementia-Applied models and digital health. Alzheimers Dement. 2023 Jul 26. doi: 10.1002/alz.13391. Epub ahead of print. PMID: 37496259.
  2. Van Kippersluis, H., Biroli, P.., Dias Perreira, R., Galama, T.J., von Hinke. S.,  Meddens, F., Muslimova, D., Slob, S., de Vlaming, Rietveld, N. (2023), Overcoming Attenuation Bias in Regressions using Polygenic Indices: A Comparison of Approaches. Nature Communications, 14, 4473 (2023). Link to working paper
  3. Bierut, L., Biroli, P., Galama, T.J., and Thom, K. (2023). Challenges in studying the interplay of genes and environment.  A study of childhood financial distress moderating genetic predisposition for peak smoking. Journal of Economic Psychology. 
  4. Klee, M, Leist, A.K., Veldsman, M., Ranson, J.M. and Llewellyn, D. J.(2023), Socioeconomic Deprivation, Genetic Risk, and Incident Dementia, American Journal of Preventive Medicine 64, no. 5 (2023): 621-630.
  5. Ward, David D; Ranson, Janice M; Wallace, Lindsay M K; Llewellyn, David J; Rockwood, Kenneth (2022), Frailty, lifestyle, genetics and dementia risk, J Neurol Neurosurg Psychiatry, 93, 343-350
  6. Kolli, Ajay; Zhou, Yunshu; Chung, Grace; Ware, Erin B; Langa, Kenneth M; Ehrlich, Joshua R (2022), Interactions between the apolipoprotein E4 gene and modifiable risk factors for cognitive impairment: a nationally representative panel study. BMC geriatrics, 22(1), 938.
  7. Tai, Xin You; Veldsman, Michele; Lyall, Donald M; Littlejohns, Thomas J; Langa, Kenneth M; Husain, Masud; Ranson, Janice; Llewellyn, David J (2022), Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. Healthy longevity (2022), 3, e428-e436
  8. Nihat, A., Ranson, J., Dominque, H., McNiven, K., Mok, T, Rudge, P., Collinge, J, Llewelyn, D., Mead, S. (2022), Development of prognostic models for survival and care status in sporadic Creutzfeldt-Jakob disease, Brain Communications, 4(4) fcac201
  9. Bakulski, K.M., Vadari, H.S., Faul, J.D., Heeringa, S.G., Kardia, S.L., Langa, K.M., Smith, J.A., Manly, J.J., Mitchell, C.M., Benke, K.S. and Ware, E.B., 2021. Cumulative genetic risk and APOE ε4 are independently associated with dementia status in a multiethnic, population-based cohort. Neurology Genetics, 7(2).
  10. Galama, T.J. and van Kippersluis, H. (2022), Economic theories of health across the life course, Elgar Handbook on Health Inequalities Across The Life Course
  11. Dias-Pereira, R., Biroli, P., Galama, T.J., von Hinke, S., van Kippersluis, H., Rietveld, C.A., and Thom, K. (2022), Gene-by-Environment Interplay in the Social Sciences. Oxford Research Encyclopedia of Economics and Finance. Working Paper.
  12. Smith, J.A., Kho, M., Zhao, W., Yu, M., Mitchell, C., Faul, J.D. (2021), Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population. Social science & medicine, 271, 112039. PubMed PMID: 30449520; PubMed Central PMCID: PMC6510651; DOI: 10.1016/j.socscimed.2018.11.019.​
  13. Faul JD, Kho M, Zhao W, Rumfelt KE, Yu M, Mitchell C, Smith JA. (2021) Trans-ethnic Meta-analysis of Interactions between Genetics and Early Life Socioeconomic Context on Memory Performance and Decline in Older Americans. J Gerontol A Biol Sci Med Sci. 2021 Aug 27:glab255. doi:10.1093/gerona/glab255. Epub ahead of print. PMID: 34448475.
  14. Siervo, Mario; Shannon, Oliver M; Llewellyn, David J; Stephan, Blossom Cm; Fontana, Luigi (2021), Mediterranean diet and cognitive function: From methodology to mechanisms of action. Free radical biology & medicine, 176 105-117
  15. Barcellos, S., Carvalho, L. and Turley, P. (2021). Distributional Effects of Education on Health, Forthcoming at the Journal of Human Resources.
  16. Kuźma, Elżbieta; Littlejohns, Thomas J; Khawaja, Anthony P; Llewellyn, David J; Ukoumunne, Obioha C; Thiem, Ulrich (2021), Visual Impairment, Eye Diseases, and Dementia Risk: A Systematic Review and Meta-Analysis, Journal of Alzheimer's disease  (JAD), 83, 1073-1087, 
  17. Fonseca, R., Michaud, P., Galama, T.J. and Kapteyn, A. (2021). Accounting for the Rise of Health Spending and Longevity. Journal of the European Economic Association,19(1), pp.536-579.
  18. Ranson, Janice M; Rittman, Timothy; Hayat, Shabina; Brayne, Carol; Jessen, Frank; Blennow, Kaj; van Duijn, Cornelia; Barkhof, Frederik; Tang, Eugene; Mummery, Catherine J; Stephan, Blossom C M; Altomare, Daniele; Frisoni, Giovanni B; Ribaldi, Federica; Molinuevo, José Luis; Scheltens, Philip; Llewellyn, David J; European Task Force for Brain Health Services (2021), Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6, Alzheimer's research & therapy, 13, 169
  19. Marees, A.T., Smit, D.J.A., Abdellaoui, A., Nivard, M.G., van den Brink, W., Denys, D., Galama, T.J., Verweij, K.J.H., Derks, E.M. (2021), Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits, Nature Human Behavior, pp.1-9.
  20. Faul, J.D., Ware, E.B., Kabeto, M.U., Fisher, J., Langa, K.M. (2021), The effect of childhood socioeconomic position and social mobility on cognitive function and change among older adults: A comparison between the United States and England, Journal of Gerontology, Series B, 76, pS51-S63.
  21. Fu, M., Bakulski, K.M., Higgins, C. and Ware, E.B. (2021). Mendelian Randomization of Dyslipidemia on Cognitive Impairment Among Older Americans. Frontiers in neurology, 12, p.1002.
  22. Ware, E.B., Morataya, C., Fu, M. and Bakulski, K.M. (2021). Type 2 Diabetes and Cognitive Status in the Health and Retirement Study: a Mendelian Randomization Approach. Frontiers in genetics, 12, p.634767.
  23. Bakulski, K.M., Vadari, H.S., Faul, J.D., Heeringa, S.G., Kardia, S.L., Langa, K.M., Smith, J.A., Manly, J.J., Mitchell, C.M., Benke, K.S. and Ware, E.B. (2021). Cumulative Genetic Risk and APOE ε4 Are Independently Associated With Dementia Status in a Multiethnic, Population-Based Cohort. Neurology Genetics, 7(2).
  24. Faul, J.D., Ware, E.B., Kabeto, M.U., Langa, K.M., Llewellyn, D.J., Galama, T. (2020), Lifestyle and Genetic Risk: Revisiting the Association with Incident Dementia. Alzheimer's & Dementia, 2020 16:e044220
  25. Zhang, Na; Ranson, Janice M; Zheng, Zhi-Jie; Hannon, Eilis; Zhou, Zhenwei; Kong, Xuejun; Llewellyn, David J; King, Daniel A; Huang, Jie (2021), Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study, Scientific reports, 11, 1295
  26. Barth, D., Papageorge, N. and Thom, K. (2020), Genetic Endowments and Wealth Inequality, Journal of Political Economy. doi: 10.1086/70541
  27. Papageorge, N. and Thom, K. (2019), Genes, Education, and Labor Market Outcomes: Evidence from the Health and Retirement Study, Journal of the European Economic Association.
  28. Clark, Christopher E; Thomas, Daniel; Llewellyn, David J; Ferrucci, Luigi; Bandinelli, Stefania; Campbell, John L (2019), Systolic inter-arm blood pressure difference and risk of cognitive decline in older people: a cohort study. The British journal of general practice : the journal of the Royal College of General Practitioners, 70, e472-e48
  29. Ware, Erin B; Faul, Jessica D; Mitchell, Colter M; Bakulski, Kelly M (2020), Considering the APOE locus in Alzheimer's disease polygenic scores in the Health and Retirement Study: a longitudinal panel study, BMC Medical Genomics, 13, 164
  30. Elliott, Emma; Green, Claire; Llewellyn, David J; Quinn, Terence J (2019), Accuracy of Telephone-Based Cognitive Screening Tests: Systematic Review and Meta-Analysis, Current Alzheimer Research, 17, 460-47
  31. Taylor, J.Y., Ware, E.B., Wright, M.L., Smith, J.A., Kardia, S.L.R. (2019), Using Genetic Burden Scores for Gene-by-Methylation Interaction Analysis on Metabolic Syndrome in African Americans. Biological Research for Nursing, 21(3): 279-285. doi: 10.1177/1099800419828486. Epub 2019 Feb 19. PubMed PMID: 30781968. 
  32. Galama, T.J. and van Kippersluis H.  (2018). A Theory of Socioeconomic Disparities in Health Over the Life Cycle. Economic Journal; Link to working paper
  33. Schmitz, L.L., Gard, A.M., Ware, E.B. (2019), Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques. American Journal of Medical Genetics, part B, Neuropsychiatric Genetics. doi: 10.1002/ajmg.b.32748. [Epub ahead of print] PubMed PMID: 31219244; NIHMSID:NIHMS1042483. 
  34. Lourida, Ilianna; Hannon, Eilis; Littlejohns, Thomas J; Langa, Kenneth M; Hyppönen, Elina; Kuzma, Elzbieta; Llewellyn, David J (2019),  Association of Lifestyle and Genetic Risk With Incidence of Dementia, JAMA, 322. 430-437, PMC ID 6231970
  35. Galama, T.J., Lleras-Muney, A. and Van Kippersluis, H. (2018), The Effect of Education on Health and Mortality: A Review of Experimental and Quasi-Experimental Evidence. Oxford Research Encyclopedia of Economics and Finance. Link to working paper. doi:10.1093/acrefore/9780190625979.013.7
  36. Kuźma, E., Lourida, A., Moore, S.F., Levine, D.A., Obioha C. Ukoumunne, O.C., Llewellyn, D.J. (2018). Stroke and dementia risk: A systematic review and meta-analysis. Alzheimers & Dementia, 1-11
  37. Kuźma, E., Hannon, E., Zhou, A., Lourida, I., Bethel, A., Levine, D.A., Lunnon, K., Thompson-Coon, J., Hyppönen, E., and Llewellyn, D.(2018), Which risk factors causally influence dementia? A systematic review of Mendelian randomization studies, Journal of Alzheimer’s Disease, 64, pp. 181–193
  38. Barcellos, S.H., Carvalho, S., Turley, P. (2018), Education can Reduce Health Differences Related to Genetic Risk of Obesity, Proceedings of the National Academy of Sciences (PNAS) of the United States  

 

WORKING PAPERS / PAPERS SUBMITTED

 

  1. Van Alten, S., Domingue, B.W., Faul J., Galama, T.J., and Marees, A.T.  (2022b), Correcting for volunteer bias in GWAS uncovers novel genetic variants and increases heritability estimates. Working Paper.
  2. Van de Kraats, C., Galama, T.J. and Lindeboom, M. (2022), Why Life Gets Better after Age 50 For Some: Mental Well-Being and the Social Norm of Work. Human Capital and Economic Opportunity Global Working Group, Working Paper 2022-040
  3. Galama, T.J. and van Kippersluis, H. (2022), Human-Capital Formation: The Importance of Endogenous Longevity. Human Capital and Economic Opportunity Global Working Group, Working Paper 2022-009 
  4. Van Alten, S., Domingue, B.W., Galama, T.J. and Marees, A.T. (2022a), Reweighting the UK Biobank to reflect its underlying sampling population substantially reduces pervasive selection bias due to volunteering. Working Paper.
  5. Carvalho, L. (2022), Genetics, Economic Choices, and Income. In preparation.
  6. Van Alten, S. and Galama, T. (2021), Genetic and environmental determinants of socioeconomic status: evidence from within-family models in the Dutch Lifelines cohort. In preparation.
  7. Aranda, R., Galama, T., and Thom, K. (2022), The Long-Run Health Consequences of Title IX. In preparation
  8. Galama, T., Munteanu, A and Thom, K. (2022), Intergenerational Consequences of Compulsory Schooling. In preparation.
  9. Barcellos, S., Carvalho, L. and Turley, P. (2021). The Effect of Education on the Relationship between Genetics, Early-Life Disadvantages, and Later-Life SES (under revision at the Journal of Political Economy). NBER Working Paper No. w28750
  10. Fu, M., Faul, J.D., Jin, Y., Ware, E.B. and Bakulski, K.M., 2021. Smoking and Dementia Status Among Older Americans: A Mendelian Randomization Analysis. Link to working paper.
  11. Fu, M., Ware, E.B., Faul, J.D., Bakulski, K.M. (2020), Mendelian randomization of smoking behavior on cognitive status among older Americans. (medRxiv) 2019.12.11.19014522; doi: https://doi.org/10.1101/2019.12.11.19014522. Link to working paper.
  12. Ware, E.B., Schmitz, L.L., Faul, J.D., Gard, A., Mitchell, C., Smith, J.A., Zhao, W., Weir, D., Kardia, S.L.R. (2019), Heterogeneity in polygenic scores for common human traits. In review.
  13. Jeong, Y., Papageorge, N.W., Skira, M.M. and Thom, K. (2021), Genetic endowments, Alzheimer's disease, and economic outcomes. In preparation.
  14. Van Alten, S., Galama, T.J. and Thom, K. (2021), The distributional consequences of region-specific exposure to Chinese import competition: evidence from a shift-share analysis (1990-2010). In preparation.
  15. Warly Solsberg, C., van Alten, S., Geier, E.G., Bonham, L., Derks, E.M., Sirota, M., Galama, T.J., Yokoyama, J.S., Marees, A.T. (2021), Conducting a genome wide association study: a roadmap and tutorial. In preparation.
  16. Angrisani, Faul, J., Galama, T. and Kabeto, M. (2021), Money Management Problems as a Precursor of Cognitive Impairment and Dementia. In preparation
  17. Biroli, P., Galama, T.J., Marees, A., et al. (2021), Sources of Inequality at Birth:  the Interplay Between Genes and Parental Socioeconomic Status. In preparation
  18. Biroli, P., Galama, T.J., von Hinke, S., van Kippersluis, H., Rietveld, C.A., and Thom, K. (2021), The Economics and Econometrics of Gene-Environment Interplay (under revision at the Review of Economic Studies). Working Paper.
  19. Bakulski, K.M., Petrowicz, B., Vadari, H., Faul, J.D., Manly, J., Kardia, S.K., Heeringa, S., Ware, E.B. (2019), Early life exposures and risk for dementia in the Health and Retirement Study. In preparation​
  20. Faul, J.D., Benke, K., Bakulski, K.M., Ware, E.B. (2019), Within and Trans-Racial PGS and Gene-Region Associations. In preparation.
  21. Brandt, D., Bakulski, K.M., Faul, J.D., Vadari, H.S., Ware, E.B. (2019) Occupational mental and physical work demands associated with cognitive status in older Americans. In preparation.
  22. Marshall III, W., Ware, E.B., Faul, J.D., Vadari, H.S., Bakulski, K.M. (2019), Family history of Alzheimer’s Disease and cumulative genetic risk in older Americans. In preparation.
  23. Mitchell CM, Faul JD, Kho M, Zhao W, Ware EB, Hillman TJ, Smith JA (2022). Genetic burden and early life socioeconomic status jointly influence memory performance and decline in older adults. Revise and Resubmit at Biodemography Soc Biol. In preparation.